Outline

We are following up the Southall and Brent cohort – the largest tri-ethnic population-based cohort in the UK. The participants were aged 40-69 when first studied between 1989 and 1991.  The focus of the study was ethnic differences in cardiometabolic disease. (See Reference 25 for baseline methods).

Most participants of African Caribbean descent had migrated from the Caribbean (92%); the remainder had migrated from West Africa. 52% of people of South Asian descent were Punjabi Sikhs, 20% were Gujarati or Punjabi Hindu, 15% were Muslim and 15% were of other South Asian origin. All African Caribbeans and South Asians were first-generation migrants.

In 2008 – 2011 we performed a comprehensive combined morbidity and mortality follow up (visit 2), together with non-invasive clinical measurements in survivors (approximately 4,000 people, then median age = 66 years) in order to quantify sub-clinical disease. We also examined primary care records (with permission) for morbid events and we asked participants about their health and lifestyles. SABRE visit 2 tested hypotheses generated from the Southall and Brent baseline studies and ongoing mortality follow-up.

Participants were invited to our clinic at St Mary’s Hospital, London W2 for detailed non-invasive clinical investigations. The Study was adopted by North West London Diabetes Research Network (DRN). Members of our research team and the DRN carried out primary care record review. 1438 people attended our clinics, we reviewed nearly 3,000 sets of GP medical records and 2010 participants completed a health and lifestyle questionnaire.

Analysis of data collected at visit 2 is ongoing, although we  have already published many findings (see publications list).

Sabre Visit 3 started in 2014 and has been funded by the British Heart Foundation. Visit 3 focusses on ethnic and sex differences in diabetes and function (cardiovascular, cognitive and physical).