The SABRE Study group

The SABRE Study group:

Nish Chaturvedi (University College London) (Principal Investigator)

David Atkinson (University College London)

Norman Beauchamp (University of Washington, Seattle)

Innocent Bvekerwa (University College London)

Emma Coady (University College London)

Rory Collins (University of Oxford)

George Davey-Smith (University of Bristol)

Hakim Moulay-Dehbi (University College London)

Sophie Eastwood (University College London)

Shah Ebrahim (London School of Hygiene and Tropical Medicine)

Hannah Elliott (University of Bristol)

Nita Forouhi (Medical Research Council Epidemiology Unit, Cambridge)

Tim Frayling (University of Exeter)

Hassina Furreed (University College London)

Wladyslaw Gedroyc (Imperial College London)

Ian Godsland (Imperial College London)

Andrew Hattersley (Peninsula Medical School, University of Exeter)

Alun Hughes (University College London)

Rolf Jäger (UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery and University College Hospital)

Siana Jones (University College London)

Daniel Key (University College London)

Azeem Majeed (Imperial College London)

April McGowan (University College London)

Jamil Mayet (Imperial College London)

Rose Mullett (University College London

Chloe Park(University College London)  

Paul McKeigue (University of Edinburgh)

Martin Prince (Kings College London)

Shonit Punwani (University College London)

Caroline Relton(University of Bristol)

Marcus Richards (Medical Research Council,Unit for Lifelong Health and Ageing)

Naveed Sattar (University of Glasgow)

Dean Shibata (University of Washington, Seattle)

Lorna Smith (University College London)

Robert Stewart (Kings College London)

Therese Tillin (University College London)

Paul Welsh(University of Glasgow)

Peter Whincup (St George’s, University of London)

Emily Williams (University College London)

Suzanne Williams (University College London)

Andrew Wright (Imperial College London)

Visit 3, the 25 year follow-up (2014-2018)

SABRE Visit 3 (25 year follow-up visit) started in July 2014 and will end in January 2018. We are grateful to the British Heart Foundation for funding this research programme.

We are inviting SABRE participants, their partners and new African Caribbean participants to come to our clinic at University College London.  We will also ask them to complete 3 questionnaires about their health and lifestyle and to give permission for us to link to some of their health-related records, for example, regarding hospital admissions and GP visits.

The aims of the study are to build on what we have learned already  from the first study and from visit 2(2008-2011).  We will measure changes in the health of the heart and circulation, with a special focus on the health of the blood vessels of the brain, as well as  early signs of diabetes.    We also want to look at physical function and how well (or otherwise) people  are keeping as they get older.

The more we understand about what causes these problems, the more likely we are to be able to work out how to prevent  or to treat them in people of all ethnicities.

In our clinic we carry out detailed measurements of blood pressure and assess the health of the heart and large and small blood vessel using non-invasive measurements, such as echocardiography.  We will carry out  MRI scans of the brain, together with a test of memory and problem solving as at visit 2. We will measure levels of glucose and fats in the blood as well as some markers of inflammation and how well the liver, kidneys and lungs  are working.  There will be some simple tests of balance and eyesight.  A short exercise test (walking) will measure how well the heart and circulation are working during exercise.

Participants and their partners  who are unable to visit our clinic can still take part in the study by completing the health and lifestyle questionnaires and /or by giving permission for us to link to  their health-related records so that we can follow-up their health.

Click here to access Participant information sheets for the study.

Diabetes during follow-up (2008-2011)

Diabetes developed in 14% Europeans, 33% Indian Asians and 30% African Caribbeans between baseline (mean age:51.8±7.0) and follow-up (mean age:70.5±6.3).  Mid-life measures of insulin resistance, and of upper body fat deposition, were already unfavourable in people who developed diabetes a decade or so later, and were more adverse in the ethnic minorities.  Insulin resistance at baseline contributed most to explaining the ethnic minority excess of diabetes in both sexes.  Of obesity measures, adjustment for truncal fat provided the most consistent and independent attenuation of the ethnic differentials in both sexes- indeed. adjustment for truncal fat largely explained the ethnic differential in diabetes incidence in women, but in men however, a two-fold excess risk of diabetes remained after adjustment for family history, conventional lifestyle and cardiometabolic risk factors.  Our findings suggest that further study of risk factors throughout the life-course and/or a search for novel risk factors is required if we are to understand why ethnic minority groups are at such high risk of developing diabetes.