Participants

SABRE is an important study first started in 1988 and involving nearly 5000 people of European , Indian Asian and African Caribbean  origins.   SABRE is investigating the causes of diabetes and disorders of the heart and circulation, as well as the reasons why some  people  stay well  in older age and why some people experience illness and disability.

If you took part in SABRE, you may remember that we first invited you take part between 1988 and 1991 when you were living in Southall and Brent in west and north-west London.  You may have been chosen from your GP practice or from your workplace (for example: British Airways, Crown Cork, Lucas CAV, Lyons Tetley, Quaker Oats).

Recently we invited participants to take part in a follow-up study (between 2008 and 2011) at our clinic at St Mary’s Hospital in Paddington.  Participants also had the option of completing a health and lifestyle  questionnaire or allowing  us to look at their GP medical records.

We have received funding from the British Heart Foundation to carry out a second follow-up study- started in 2014 at University College London. This time we are also inviting the partners of the original study participants to join the study, together with new African and African Caribbean participants. This phase of follow-up will end in January 2018.

SABRE study publications new in 2015

We are still working hard on analysing the data that we have collected since 1989 and a clutch of new manuscripts have been accepted for publication in scientific journals.

Recently (Diabetologia 2015, in press,http://dx.doi.org/10.1007/s00125-015-3517-8) we found that higher levels of some amino acids, in particular tyrosine, were already present in non-diabetic South Asian individuals back in 1989-91. Some of these amino acids, again especially tyrosine, more strongly predicted later development of type 2 diabetes in the South Asian people than in the Europeans in our study, even after adjustment for other risk factors such as obesity and insulin resistance. A given increase (one standard deviation) in tyrosine increased risk of developing diabetes by just 10% in Europeans, while in South Asians the increase in risk was 47%.

This study has fitted another piece of the jigsaw of complicated underlying reasons as to why South Asians are at such high risk of developing type 2 diabetes compared with European origin populations. This is the first study that has looked at the links between amino acid levels (the building blocks of proteins) and the future development of diabetes in people of both European and South Asian origins living in one geographical area. Disturbances of amino acid are likely to occur in the liver, kidneys, muscle and adipose tissues. We don’t pretend to have all the answers, but believe that our findings suggest that amino acid disturbances (in particular tyrosine) may be a focus for future research, paving the way for better prevention and potentially for targeted treatments in South Asian individuals.

In another recent manuscript (Psychological Medicine, 2015, http://www.ncbi.nlm.nih.gov/pubmed/25677948) we found that people of South Asian, African or African–Caribbean origins were significantly more likely to have depressive symptoms than people of European origin. These symptoms were most explained (but not entirely) by physical health in the South Asians and by socioeconomic disadvantage in the African and African-Caribbean groups. The study highlights the need to build on understanding for these ethnic differences and to identify opportunities for interventions to address inequalities.

The first follow-up (2008-2011)

4857 people took part in the first studies between 1988 and 1991.  Of these

  • 3433 were still alive and living in the  UK in 2008
  • The average age of participants in 2008 was  70 years(range: 57-90)
  • Between 2008 and 2011, 1438 people visited our clinic at St Mary’s for follow-up, another 29 people had some measurements done at home.
  • 2011 people completed a follow-up questionnaire about their health and lifestyle
  • 1872 people gave permission for us to study their GP medical records so that we could record heart and circulatory diseases and diabetes that have developed during the 20 years since the study started.

This was a fantastic response after 20 years, involving over 60% of participants.  We are truly grateful for their help.  Their efforts have been put to good use and we’re busy analysing all the information that we collected- this involves statistical analysis and scientific interpretation.   We have already published several papers  and there is much more work to be done.

We would also like to remember the 1124 people who have died since the first studies.  They too gave their time to this research in its early days and we did not wish for their contribution to be lost.  With special permissions, we have been able to obtain information regarding their health before they died.

We are currently carrying out  another follow-up (2014-18) at University College London.This is funded by  the British Heart Foundation.

Publications

Papers from SABRE V2 follow up (updated June 2017)

  1. Siana Jones, Therese Tillin, Suzanne Williams, Emma Coady, Nishi Chaturvedi and Alun D. Hughes. Assessment of Exercise Capacity and Oxygen Consumption Using a 6 min Stepper Test in Older Adults. Front. Physiol., 14 June 2017 doi: 10.3389/fphys.2017.00408
  2. Associations Between Left Ventricular Dysfunction and Brain Structure and Function: Findings From the SABRE (Southall and Brent Revisited) Study. Park CM, Williams ED, Chaturvedi N, Tillin T, Stewart RJ, Richards M, Shibata D5, Mayet J, Hughes AD. J Am Heart Assoc. 2017 Apr 18;6(4). pii: e004898. doi: 10.1161/JAHA.116.004898
  3. Dehbi HM, Blangiardo M, Gulliver J, Fecht D, de Hoogh K, Al-Kanaani Z, Tillin T, Hardy R, Chaturvedi N, Hansell AL. Air pollution and cardiovascular mortality with over 25years follow-up: A combined analysis of two British cohorts. Environ Int. 2016 Dec 7. pii: S0160-4120(16)30950-3. doi: 10.1016/j.envint.2016.12.004. [Epub ahead of print]
  4. Lotta LA, Scott RA, Sharp SJ, Burgess S, Luan J, Tillin T, Schmidt AF, Imamura F, Stewart ID, Perry JR, Marney L, Koulman A, Karoly ED, Forouhi NG, Sjögren RJ, Näslund E, Zierath JR, Krook A, Savage DB, Griffin JL, Chaturvedi N, Hingorani AD, Khaw KT, Barroso I, McCarthy MI, O’Rahilly S, Wareham NJ, Langenberg C. Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis. PLoS Med. 2016 Nov 29;13(11):e1002179. doi: 10.1371/journal.pmed.1002179.
  5. Peter Würtz, Qin Wang, Pasi Soininen, Antti J. Kangas, Ghazaleh Fatemifar, Tuulia Tynkkynen, Mika Tiainen, Markus Perola, Therese Tillin, Alun D. Hughes, Pekka Mäntyselkä, Mika Kähönen, Terho Lehtimäki, Naveed Sattar, Aroon D. Hingorani, Juan-Pablo Casas, Veikko Salomaa, Mika Kivimäki, Marjo-Riitta Järvelin, George Davey Smith, Mauno Vanhala, Debbie A. Lawlor, Olli T. Raitakari, Nish Chaturvedi, Johannes Kettunen, Mika Ala-Korpela. Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase. J Am Coll Cardiol. 2016 March 15; 67(10): 1200–1210. doi: 10.1016/j.jacc.2015.12.060, PMCID: PMC4783625
  6. Park CM, Tillin T, Jones S, Whincup PH, Mayet J, Chaturvedi N, Hughes AD. Adverse effect of diabetes and hyperglycaemia on arterial stiffness in Europeans, South Asians, and African Caribbeans in the SABRE study.  J Hypertens. 2016 Feb; 34(2):282-9.
  7. Eastwood SV, Tillin T, Sattar N, Forouhi NG, Hughes AD, Chaturvedi N. Associations Between Prediabetes, by Three Different Diagnostic Criteria, and Incident CVD Differ in South Asians and Europeans. Diabetes Care. 2015 Dec;38(12):2325-32. doi: 10.2337/dc15-1078. 2015 Dec;38(12):2325-32.
  8. Eastwood SV, Tillin T, Chaturvedi N, Hughes AD. Ethnic Differences in Associations Between Blood Pressure and Stroke in South Asian and European Men.  Hypertension. 2015 Sep;66(3):481-8. doi: 10.1161/HYPERTENSIONAHA.115.05672. Epub 2015 Jul 13.
  9. Eastwood SV, Tillin T, Mayet J, Shibata DK, Wright A, Heasman J, Beauchamp N, Forouhi NG, Hughes AD, Chaturvedi N.  Ethnic differences in cross-sectional associations between impaired glucose regulation, identified by oral glucose tolerance test or HbA1c values, and cardiovascular disease in a cohort of European and South Asian origin. Diabet Med. 2015 Aug 28. doi: 10.1111/dme.12895. [Epub ahead of print]
  10. T Tillin, AD Hughes, Q Wang, P Wurtz, M Ala-Korpela, N Sattar, NG Forouhi, IF Godsland, S Eastwood, PM McKeigue, N Chaturvedi. Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study. Diabetologia2015 May;58(5):968-79. http://dx.doi.org/10.1007/s00125-015-3517-8
  11. Sophie V Eastwood, Therese Tillin, Hakim-Moulay Dehbi, Andrew Wright, Nita G Forouhi, Ian Godsland, Peter Whincup, Naveed Sattar, Alun D Hughes, Nishi Chaturvedi. Ethnic Differences in Associations Between Fat Deposition and Incident Diabetes and Underlying Mechanisms: The SABRE Study. Obesity (Silver Spring) 2015 March; 23(3): 699–706. Published online 2015 February 3. doi: 10.1002/oby.20997. PMCID: PMC4463764.
  12. Eriksen A, Tillin T, O’Connor L, Brage S, Hughes A, Mayet J, McKeigue P, Whincup P, Chaturvedi N, Forouhi NG. The Impact of Health Behaviours on Incident Cardiovascular Disease in Europeans and South Asians – A Prospective Analysis in the UK SABRE Study. PLoS One. 2015 Mar 2;10(3):e0117364. doi: 10.1371/journal.pone.0117364 . eCollection 2015.
  13. Eastwood SV, Tillin T, Dehbi HM, Wright A, Forouhi NG, Godsland I, Whincup P, Sattar N, Hughes AD, Chaturvedi N. Ethnic differences in associations between fat deposition and incident diabetes and underlying mechanisms: The SABRE study. Obesity (Silver Spring). 2015 Feb 3. http://dx.doi.org/10.1002/oby.20997
  14. Williams ED, Tillin T, Richards M, Tuson C, Chaturvedi N, Hughes AD, Stewart R. Depressive symptoms are doubled in older British South Asian and Black Caribbean people compared with Europeans: associations with excess co-morbidity and socioeconomic disadvantage. Psychol Med. 2015 Feb 13:1-11.http://www.ncbi.nlm.nih.gov/pubmed/25677948  [Epub ahead of print]
  15. Williams ED, Eastwood SV, Tillin T, Stewart R, Chaturvedi N, Hughes AD. Statin use is associated with reduced depressive symptoms in Europeans, but increased symptoms in ethnic minorities in UK: An observational study.Br J Clin Pharmacol. 2015 Feb 2. http://dx.doi.org/10.1111/bcp.12599. [Epub ahead of print]
  16. Tillin T, Sattar N, Godsland IF, Hughes AD, Chaturvedi N, Forouhi NG. Ethnicity-specific obesity cut-points in the development of type 2 diabetes – a
    prospective study including three ethnic groups in the United Kingdom. Diabetic Medicine 2015 Feb;32(2):226-34
  17. Eastwood SV, Tillin T, Wright A, Mayet J, Godsland I, Forouhi NG, Whincup P, Hughes AD, Chaturvedi. Thigh fat and muscle each contribute to excess cardiometabolic risk in South Asians, independent of visceral adipose tissue. Obesity (Silver Spring). N. 2014 Sep;22(9):2071-9. http://dx.doi.org/10.1002/oby.20796
  18. Williams ED, Eastwood SV, Tillin T, Hughes AD, Chaturvedi N. The effects of weight and physical activity change over 20 years on later-life objective and self-reported disability. Int J Epidemiol. 2014 Feb 20. Epub ahead of print.
  19. Elliott HR, Tillin T, McArdle WL, Ho K, Duggirala A, Frayling TM, Davey Smith G, Hughes AD, Chaturvedi N, Relton CL. Differences in smoking associated DNA methylation patterns in South Asians and Europeans. Clin Epigenetics. 2014. 2014 Feb 3;6(1):4. http://dx.doi.org/10.1186/1868-7083-6-4
  20. Park CM, Korolkova O, Davies JE, Parker KH, Siggers JH, March K, Tillin T, Chaturvedi N, Hughes AD. Arterial pressure: agreement between a brachial cuff-based device and radial tonometry. J Hypertens 2014 Apr;32(4):865-72. http://dx.doi.org/10.1097/HJH.0000000000000082
  21. Park CM, Tillin T, March K, Ghosh AK, Jones S, Wright A, Heasman J, Francis D, Sattar N, Mayet J, Chaturvedi N<, Hughes AD. Hyperglycaemia Has A Greater Impact On Left Ventricle Function In South Asians Than Europeans. Diabetes Care.2014 Apr;32(4):1124-31. http://dx.doi.org/10.2337/dc13-1864. Epub 2013 Nov 15.
  22. Tillin T, Hughes AD, Whincup P, Mayet J, Sattar N, McKeigue PM, Chaturvedi N. Ethnicity and prediction of cardiovascular disease. Performance of QRISK2 and Framingham scores in a UK tri-ethnic prospective cohort study (SABRE: Southall and Brent Revisited). Heart. 2014 Jan;100(1):60-7. http://dx.doi.org/10.1136/heartjnl-2013-304474
  23. Eastwood SV, Tillin T, Wright A, Heasman J, Willis J, Godsland IF, Forouhi N, Whincup P, Hughes AD, Chaturvedi N. Estimation of CT-Derived Abdominal Visceral and Subcutaneous Adipose Tissue Depots from Anthropometry in Europeans, South Asians and African Caribbeans. PLoS One. 2013 Sep 17;8(9):e75085. http://dx.doi.org/10.1371/journal.pone.0075085
  24. Shibata D, Tillin T, Beauchamp N, Heasman J, Hughes AD, Park C, Gedroyc W, Chaturvedi N. African Caribbeans have greater subclinical cerebrovascular disease than Europeans: this is associated with both their elevated resting and ambulatory blood pressure and their hyperglycaemia. J Hypertens.2013 Dec;31(12):2391-9. http://dx.doi.org/10.1097/HJH.0b013e328364f5bc
  25. Park CM, March K, Williams S, Kukadia S, Ghosh AK, Jones S, Tillin T, Chaturvedi N, Hughes AD. Feasibility and reproducibility of left ventricular rotation by speckle tracking echocardiography in elderly individuals and the impact of different software. PLoS One. 2013 Sep 13;8(9):e75098. http://dx.doi.org/10.1371/journal.pone.0075098
  26. Taylor C , Tillin T, Chaturvedi N , Dewey M , Ferri CP, Hughes AD , Prince M, Richards M, Shah A , Stewart R . Mid-life hypertensive status and cognitive function 20 years later: the SABRE study. Journal of the American Geriatric Society. 2013 Sep;61(9):1489-98. http://dx.doi.org/10.1111/jgs.12416 .
  27. Park C, March K, Ghosh A, Jones S, Coady E, Tuson C, Baker M, Mayet J, Tillin T, Chaturvedi N, Hughes AD. Left ventricular structure in the SABRE Study: Explaining ethnic differences. Hypertension, 2013 May;61(5):1014-20. http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.00610
  28. Tillin T, Hughes AD, Mayet J, Whincup P, Sattar N, Forouhi NG, McKeigue PM, Chaturvedi N. The relationship between metabolic risk factors and incident cardiovascular disease in Europeans, South Asians and African Caribbeans. SABRE (Southall and Brent revisited) – a prospective population based study. J Am Coll Cardiol. 2013 Apr 30;61(17):1777-86. http://dx.doi.org/10.1016/j.jacc.2012.12.046
  29. Tillin T, Hughes AD, Godsland IF, Whincup P, Forouhi NG, Welsh P, Sattar N, McKeigue PM, Chaturvedi N. Insulin resistance and truncal obesity as important determinants of the greater incidence of diabetes in Indian Asians and African Caribbeans compared to Europeans? The Southall And Brent REvisited (SABRE) cohort. Diabetes Care 2013;36(2)(383-393). http://care.diabetesjournals.org/content/36/2/383.long
  30. Williams ED, Tillin T, Whincup P, Forouhi N, Chaturvedi N. Ethnic differences in disability over 20 years: A cohort study. PLoS One 2012;7(9):e45602. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045602
  31. Tillin T, Forouhi NG, McKeigue PM, Chaturvedi N. Southall And Brent REvisited: Cohort profile of SABRE, a UK population- based comparison of cardiovascular disease and diabetes in people of European, Indian Asian and African Caribbean origins. Int J Epidemiol 2012 November 1. http://dx.doi.org/10.1093%2Fije%2Fdyq175
  32. Tillin T, Forouhi NG, Davey-Smith G, McKeigue PM, Chaturvedi N. Cardiovascular Disease Mortality in Relation to Childhood and Adulthood Socio-Economic Markers in British South Asian Men. Heart 2008 April;94(4):476-81. http://heart.bmj.com/content/94/4/476.full?sid=69589b19-7212-4592-b38b-93994f452b9e http://dx.doi.org/10.1007%2Fs00125-005-1689-3
  33. Tillin T, Forouhi N, McKeigue P, Chaturvedi N. Microalbuminuria and coronary heart disease risk in an ethnically diverse UK population: a prospective cohort study. J Am Soc Nephrol 2005; 16(12):3702-3710. http://dx.doi.org/10.1681%2FASN.2005060584
  34. Tillin T, Forouhi NG, McKeigue PM, Chaturvedi N. The Role of Diabetes and Components of the Metabolic Syndrome in Stroke and Coronary Heart Disease Mortality in U.K. White and African-Caribbean Populations. Diabetes Care 2006; 29(9):2127-2129. http://dx.doi.org/10.2337%2Fdc06-0779
  35. Forouhi NG, Sattar N, Tillin T, McKeigue PM, Chaturvedi N. Do known risk factors explain the higher coronary heart disease mortality in South Asian compared with European men? Prospective follow-up of the Southall and Brent studies, UK. Diabetologia 2006; 49:2580-2588. http://dx.doi.org/10.1007%2Fs00125-006-0393-2

Abstracts from SABRE follow up(updated May 2014)

  1. Southall and Brent Revisited (SABRE) cohort. Tillin T. Diabetes UK , Liverpool, March 2014.
  2. Total Arterial Elastance is more strongly associated with cardiovascular disease than carotid-femoral pulse wave velocity.   Park C, March K, Ghosh A, Tillin T, Chaturvedi N, Hughes AD. Artery 13, London October 2013.
  3. Ethnic differences in associations between carotid IMT, coronary artery calcification and cerebrovascular disease. A population based study of Europeans, South Asians and African Caribbeans(SABRE). Tillin T, March K, Heasman J, Park C, Beauchamp N, Shibata D, Wright A, Hughes AD, Chaturvedi N. Artery 13, October 2013, London.
  4. Effect of diabetes and hyperglycaemia on the left ventricle – does it differ with ethnicity? Park CM, March K, Jones S, Tuson C, Ghosh AK, Coady E, Tillin T, Mayet J, Chaturvedi N , Hughes AD. European Association for the Study of Diabetes, Barcelona, September 2013
  5. Ethnic differences in associations between fat deposition and incident diabetes. Sophie Eastwood, Therese Tillin, Andrew Wright, John Heasman, Alun Hughes, Nish Chaturvedi. European Association for the Study of Diabetes, Barcelona, September 2013
  6. Ethnicity-specific obesity cut-points in the development of incident diabetes – a prospective study (SABRE) including three ethnic groups in the United Kingdom. Tillin T, Sattar N, Godsland IF, Hughes AD, Chaturvedi N, Forouhi N. European Association for the Study of Diabetes, Barcelona, September 2013
  7. Pulse Pressure is more strongly associated with incident CHD in South Asians than in Europeans. Tillin T, Tuson C, Coady E, Chaturvedi N, Hughes AD. British Hypertension Society, London September 2013
  8. Ethnic differences in central haemodynamics and central arterial stiffness. Park C, March K, Tillin T, Chaturvedi N, Hughes AD. British Hypertension Society, London September 2013
  9. Greater Impact of hyperglycaemia on macrovascular function in South Asians than in Europeans. Could this contribute to their excess cardiovascular risk. Park C, March K, Tillin T, Hughes AD, Chaturvedi N. FINNDIANE, Helsinki, June 2013
  10. Explanations for reduced left ventricle longitudinal function in South Asians. Park C, Ghosh A, Hughes A, Chaturvedi N. European Atherosclerosis Society, Lyon, June 2013
  11. Statin use is associated with depression in minority ethnic groups in UK. ED Williams, Stewart R, T Tillin, N Chaturvedi, AD Hughes. European Atherosclerosis Society, Lyon, June 2013
  12. Different associations between visceral and subcutaneous adiposity and coronary artery calcification. SV Eastwood, T Tillin, J Heasman, A Wright, AD Hughes, N Chaturvedi. European Atherosclerosis Society, Lyon, June 2013
  13. Peripheral blood pressure measurement underestimates central systolic blood pressure in obese individuals. Park C, March K, Tillin T, Hughes AD, Chaturvedi N. European Society for Hypertension, Milan, June 2013
  14. Apolipoprotein B : A1 ratio is independently associated with sub-clinical and incident coronary heart disease in British South Asian and European men. Tillin T, Godsland I, Sattar N, Hughes A, Chaturvedi N. European Atherosclerosis Society, Lyon, June 2013
  15. Are ethnic differences in central pulse pressure explained by hyperglycaemia? Park CM, March K, Tillin T, Hughes AD, Chaturvedi N. European Atherosclerosis Society, Lyon, June 2013.
  16. Visceral adiposity in South Asians has a greater detrimental impact on cardiometabolic risk factors than Europeans. SV Eastwood, T Tillin, J Heasman, A Wright, AD Hughes, N Chaturvedi. Diabetes UK Manchester. March 2013
  17. Association between depression and health outcomes in people with type 2 diabetes: Do the relationships vary by ethnic group? ED Williams, T Tillin, N Chaturvedi, M Baker, R Stewart . Diabetes UK Manchester. March 2013
  18. Do risk factors measured 20 years previously predict and explain ethnic differences in HbA1c among non-diabetic British South Asians, African Caribbeans and Europeans? Tilln T, Hughes A, Godsland I, Tuson C, Sattar N, Chaturvedi N. Diabetes UK Manchester . March 2013.
  19. Ethnic differences in left ventricle structure- is 2D echocardiography misleading? Park CM, March K, Jones S, Ghosh AK, Tillin T, Chaturvedi N, Hughes AD. Euroecho, Vienna, Nov 2012.
  20. Ethnic differences in left ventricle myocardial oxygen demand. Park C, Ghosh A, Tillin T, Hughes A, Chaturvedi N. Artery, Vienna Oct 2012.
  21. Ethnic differences in wave intensity and arterial stiffness in the carotid artery. Park C, March K, Tillin T, Hughes A, Chaturvedi N. Artery Vienna Oct 2012
  22. A method comparison of central blood pressure measurements by Pulsecor and Sphygmocor devices. Park C, Davies J, Chaturvedi N, Hughes AD. International Society of Hypertension , Sydney, 2012
  23. Ethnic differences in wave intensity and arterial stiffness in the carotid artery. Park C, March K, Tillin T, Chaturvedi N, Hughes AD. Artery , Vienna, October 2012
  24. Increased left ventricular elastance at end-ejection is associated with lower arterial compliance and reduced ventricular relaxation. Reesink K, Park C, Davies J, Chaturvedi N, Hughes AD. Artery , Vienna, October 2012
  25. Ethnic differences in Left Ventricular structure-is 2D echocardiography misleading? Park C, March K, Jones S, Mayet J, Tillin T, Chaturvedi N, Hughes AD. EuroEcho, Athens, 2012
  26. Ethnic differences in the development of disability over 20 years: Results from the SABRE study. Williams ED, Tillin T, Chaturvedi N. Society for Social Medicine, London Sept 2012
  27. Hyperglycaemia and diastolic function: does ethnicity matter?     Park C, March K, Tillin T, Mayet J, Chaturvedi N, Hughes AD . EuroEcho, Budapest Nov 2011
  28. Excess diabetes in ethnic minorities- incidence and predictors. Tillin T, Hughes AD, Whincup P, Forouhi N, Sattar N, McKeigue P, Chaturvedi N. European Association for the Study of Diabetes, Lisbon Sept 2011.
  29. Effect of diabetes and hyperglycaemia on the left ventricle -does it differ with ethnicity? Park C, March K, Tillin T, Mayet J, Chaturvedi N, Hughes AD           European Association for the Study of Diabetes, Lisbon Sept 2011
  30. Relation of Changes in Components of the Metabolic Syndrome to Changes in Fat Depots in a Cardiovascular Prevention Programme. Jenni S, Tillin T, March K, Tuson C, Park C, Baker M, Fitzpatrick J, Thomas E, Bell J, Connolly S, Wood D, Hughes A, Chaturvedi N. European Association for the Study of Diabetes, Lisbon Sept 2011
  31. Subclinical measures of atherosclerosis associate differently with prevalent coronary heart disease in Indian Asians and Europeans   . Tillin T, Heasman J, Wright W, Chaturvedi N, Hughes AD. Artery , Paris Sept 2011
  32. Despite higher rates of coronary heart disease in British Indian Asians, coronary artery calcification levels are equivalent to those of Europeans              Tillin T, Heasman J, Wright W, Chaturvedi N, Hughes AD. European Society of Cardiology, Paris. August 2011
  33. Reproducibility of left ventricular rotation by speckle tracking on echocardiography and the impact of different software. Park C, March K, Ghosh AK, Jones S, Mayet J, Tillin T, Chaturvedi N, Hughes AD. European Society of Cardiology, Paris. August 2011
  34. Rapid reductions in left ventricular mass following a community based 12-week prevention programme are partially predicted by change in fat depots. Jenni S, Tillin T, Park C, Baker M, Thomas E, Bell J, Connolly S, Wood D, Hughes A, Chaturvedi N. European Society of Cardiology, Paris. August 2011
  35. Is speckle tracking echocardiography a valid tool to assess left ventricular rotation in elderly individuals? Park C, March K, Ghosh AK, Jones S, Mayet J, Tillin T, Chaturvedi N, Hughes AD. Physiological fluid mechanics, Brunel, London. July 2011

Papers from baseline investigation

  1. McKeigue PM, Shah B, Marmot MG. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet 1991; 337:382-386. http://dx.doi.org/10.1016%2F0140-6736%2891%2991164-P
  2. Renges HH, Wile DB, McKeigue PM, Marmot MG, Humphries SE. Apolipoprotein B gene polymorphisms are associated with lipid levels in men of South Asian descent. Atheroscler 1991 December;91:267-75. http://dx.doi.org/10.1016%2F0021-9150%2891%2990174-2
  3. McKeigue PM, Pierpoint T, Ferrie JE, Marmot MG. Relationship of glucose intolerance and hyperinsulinaemia to body fat pattern in south Asians and Europeans. Diabetologia 1992; 35:785-791. http://www.springerlink.com/content/u06310270xkq4324/
  4. McKeigue PM, Ferrie JE, Pierpoint T, Marmot MG. Association of early-onset coronary heart disease in South Asian men with glucose intolerance and hyperinsulinemia. Circulation 1993 January;87:152-61. http://dx.doi.org/10.1161%2F01.CIR.87.1.152
  5. McKeigue PM, Laws A, Chen YD, Marmot MG, Reaven GM. Relation of plasma triglyceride and apoB levels to insulin-mediated suppression of nonesterified fatty acids. Possible explanation for sex differences in lipoprotein pattern. Arterioscler Thromb 1993 August;13:1187-92. http://dx.doi.org/10.1161%2F01.ATV.13.8.1187
  6. Chaturvedi N, McKeigue PM, Marmot MG. Resting and ambulatory blood pressure differences in Afro-Caribbeans and Europeans. Hypertension 1993; 22:90-96. http://dx.doi.org/10.1161%2F01.HYP.22.1.90
  7. Chaturvedi N, Athanassopoulos G, McKeigue PM, Marmot MG, Nihoyannopoulos P. Echocardiographic measures of left ventricular structure and their relation with rest and ambulatory blood pressure in blacks and whites in the United Kingdom. J Am Coll Cardiol 1994; 24:1499-1505. http://dx.doi.org/10.1016%2F0735-1097%2894%2990146-5
  8. Sevak L, McKeigue PM, Marmot MG. Relationship of hyperinsulinemia to dietary intake in south Asian and European men. Am J Clin Nutr 1994; 59:1069-1074. http://www.ajcn.org/content/59/5/1069.full.pdf+html?sid=3e56367a-5b0d-4de7-9038-17eaf141910a
  9. Chaturvedi N, McKeigue PM, Marmot MG. Relationship of glucose intolerance to coronary risk in Afro-Caribbeans compared with Europeans. Diabetologia 1994; 37:765-772. http://dx.doi.org/10.1007%2FBF00404333
  10. Sharp PS, Chaturvedi N, Wormald R, McKeigue PM, Marmot MG, Young SM. Hypertensive retinopathy in Afro-Caribbeans and Europeans. Prevalence and risk factor relationships. Hypertension 1995; 25:1322-1325. http://dx.doi.org/10.1161%2F01.HYP.25.6.1322
  11. Chaturvedi N, McKeigue P, Nihoyannopoulos P. Ethnic differences in left ventricular changes associated with blood glucose. Diabetic Med. 15 suppl 2, S53-S54. 1998. Ref Type: Abstract
  12. Pomerleau J, McKeigue PM, Chaturvedi N. Factors associated with obesity in South Asian, Afro-Caribbean and European women. Int J Obes Relat Metab Disord 1999 January;23(1):25-33. http://dx.doi.org/10.1038%2Fsj.ijo.0800750
  13. Pomerleau J, McKeigue PM, Chaturvedi N. Relationships of fasting and postload glucose levels to sex and alcohol consumption. Are American Diabetes Association criteria biased against detection of diabetes in women? Diabetes Care 1999; 22(3):430-433. http://dx.doi.org/10.2337%2Fdiacare.22.3.430
  14. Chaturvedi N, McKeigue PM, Marmot MG, Nihoyannopoulos P. A comparison of left ventricular abnormalities associated with glucose intolerance in African Caribbeans and Europeans in the UK. Heart 2001; 85:643-648. http://dx.doi.org/10.1136%2Fheart.85.6.643
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What is SABRE?

The Southall And Brent REvisited Study (SABRE) is a medical research study involving nearly 5000 European, Indian Asian and African Caribbean men and women. SABRE is funded by two registered charities, the Wellcome Trust and British Heart Foundation and is run by a team now based at University College London with support from experts at the Universities of Bristol, Cambridge, Edinburgh, Exeter, Glasgow, Newcastle, Oxford and Washington (Seattle, USA).

Press

Recently Princess Anne visited us to open our new unit at the Institute of Cardiovascular Science, University College London. Some of the SABRE study participants joined us on the day.

The video news clip is taken from a BBC London News broadcast of July 17th 2008 and gives an idea of the background to the SABRE Study. Two of our study participants kindly agreed to be filmed undergoing some of the tests and talking about their experiences.